The Headache of a Hyperactive Calcium Channel
نویسندگان
چکیده
Migraine is thought to be triggered by excessive neocortical neuronal excitability that leads to cortical spreading depression. In this issue of Neuron, Tottene et al. study a mouse model of familial hemiplegic migraine type 1, and provide evidence for the hyperactivity of P/Q-type calcium channel-mediated cortical glutamatergic synaptic transmission as an underlying mechanism for the susceptibility of cortical spreading depression initiation in migraine disorders.
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عنوان ژورنال:
- Neuron
دوره 61 شماره
صفحات -
تاریخ انتشار 2009